Postnatal Development of A-type and Kv1- and Kv2-mediated Potassium Channel
نویسندگان
چکیده
1 Currents in Neocortical Pyramidal Neurons. 2 3 Running title: Development of K currents 4 5 6 Dongxu Guan, Leslie R. Horton, William E. Armstrong, and Robert C. Foehring 7 University of Tennessee Health Science Center 8 Department of Anatomy and Neurobiology 9 855 Monroe Avenue 10 Memphis, TN 38163 11 12 Corresponding author: 13 Robert C. Foehring 14 University of Tennessee Health Science Center 15 Department of Anatomy and Neurobiology 16 855 Monroe Avenue 17 Memphis, TN 38163 18 19 Phone: 901-448-7450 20 Fax: 901-448-7193 21 e-mail: [email protected] 22 23 24 25 Articles in PresS. J Neurophysiol (March 30, 2011). doi:10.1152/jn.00758.2010
منابع مشابه
Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.
Potassium channels regulate numerous aspects of neuronal excitability, and several voltage-gated K(+) channel subunits have been identified in pyramidal neurons of rat neocortex. Previous studies have either considered the development of outward current as a whole or divided currents into transient, A-type and persistent, delayed rectifier components but did not differentiate between current co...
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Four alpha-subunits are thought to coassemble and form a voltage-dependent potassium (Kv) channel. Kv alpha-subunits belong to one of four major subfamilies (Kv1, Kv2, Kv3, Kv4). Within a subfamily up to eight different genetic isotypes exist (e.g., Kv1.1, Kv1.2). Different isotypes within the Kv1 or Kv3 subfamily coassemble. It is not known, however, whether the only two members of the vertebr...
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After block of Kv1- and Kv2-mediated K(+) currents in acutely dissociated neocortical pyramidal neurons from layers II/III of rat somatosensory and motor cortex, the remaining current is slowly activating and persistent. We used whole cell voltage clamp to show that the Kv7 blockers linopirdine and XE-991 blocked a current with similar kinetics to the current remaining after combined block of K...
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Kv1.1 and Kv1.4 potassium channels have different pore region determinants that were found to affect their cell-surface levels positively and negatively [Zhu, Watanabe, Gomez and Thornhill (2001) J. Biol. Chem. 276, 39419-39427; Zhu, Watanabe, Gomez and Thornhill (2003) J. Biol. Chem. 278, 25558-25567; Zhu, Watanabe, Gomez and Thornhill (2003) Biochem. J. 375, 761-768]. In the present study, we...
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A non inactivating potassium current known as the delayed rectifier plays a major role in membrane repolarization during an action potential. Whereas several candidate genes exist that code for potassium current, the identities of the molecular isotypes that are responsible in situ for membrane repolarization remain unidentified. We report that Kv2 channels play a major role in action potential...
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